Diabinese (Chlorpropamide)

Generic name: Chlorpropamide

Diabinese is an oral antidiabetic medication used to treat Type II (non-insulin-dependent) diabetes. Diabetes occurs when the body fails to produce enough insulin or in unable to use it properly. Insulin is believed to work by helping sugar penetrate the cell wall so it can be used by the cell.

There are two forms of diabetes: Type I insulin-dependent and Type II non-insulin-dependent. Type I usually requires insulin injection for life, while Type II diabetes can usually be treated by dietary changes and oral antidiabetic medications such as Diabinese. Apparently, Diabinese controls diabetes by stimulating the pancreas to secrete more insulin. Occasionally, Type II diabetics must take insulin injections on a temporary basis, especially during stressful periods or times of illness.

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Side Effects
as reported by "The PDR® Family Guide To Prescription Drugs®"

Most important fact about this drug:
Always remember that Diabinese is an aid to, not a substitute for, good diet and exercise. Failure to follow a sound diet and exercise plan can lead to serious complications, such as dangerously high or low blood sugar levels. Remember, too, that Diabinese is not an oral form of insulin, and cannot be used in place of insulin.

More common side effects may include:
Diarrhea, hunger, itching, loss of appetite, nausea, stomach upset, vomiting

Less common side effects may include:
Anemia and other blood disorders, hives, inflammation of the rectum and colon, sensitivity to light, yellowing of the skin and eyes

Diabinese, like all oral antidiabetics, can cause hypoglycemia (low blood sugar). The risk of hypoglycemia is increased by missed meals, alcohol, other medications and excessive exercise. To avoid hypoglycemia, closely follow the dietary and exercise regimen suggested by your physician.

Symptoms of mild hypoglycemia may include:
Cold sweat, drowsiness, fast heartbeat, headache, nausea, nervousness

Symptoms of more severe hypoglycemia may include:
Coma, pale skin, seizures, shallow breathing

Contact your doctor immediately if these symptoms of severe low blood sugar occur.

Special warnings about this medication:
It’s possible that drugs such as Diabinese may lead to more heart problems than diet treatment alone, or diet plus insulin. If you have a heart condition, you may want to discuss this with your doctor.

If you are taking Diabinese, you should check your blood and urine periodically for the presence of abnormal sugar levels.

Remember that it is important that you closely follow the diet and exercise regimen established by your doctor.

Even people with well-controlled diabetes may find that stress, illness, surgery, or fever results in a loss of control. If this happens, your doctor may recommend that Diabinese be discontinued temporarily and insulin used instead.

In addition, the effective of any oral antidiabetic, including Diabinese, may decrease with time. This may occur because of either a diminished responsiveness to the medication or a worsening of the diabetes.

The "PHYSICIAN'S DESK REFERENCE®", and PDR® are registered trademarks owned by Medical Economics.

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